The UK Prostate Nutritional Intervention Study
Background:
This study is evaluated the impact of an intervention which aims to improve gut health, increase vitamin D and boost phytochemical rich food intake among men with prostate cancer. It was approved by the UK national Ethics committee (IRAS number: 321309) and internationally registered (ISRCTN: 81939514). To improve gut health the scientific committee chose the Yourgutplus blend as it has a proven track record both for safety and effectiveness. This national, ethically approved RCT started in September 2023 and completed September 2024. It aimed to establish whether boosting the diet with a vitamin D, lactobacillus probiotic (Yourgutplus) in addition to a phytochemical-rich food supplement (Yourphyto) will influence:
- PSA progression,
- MRI changes over time
- prostate-related urinary symptoms and erectile function
The intervention:
The probiotic capsule will contain 10 billion colony forming units (CFU) of 5 lactobacillus strains with built-in prebiotics. The phytochemical-rich capsule will contain whole foods which have previously reported potential benefits for men with prostate cancer in epidemiological, laboratory and prospective studies. The scientific committee decided on this particular phytochemical-rich blend following a formal review of the international scientific literature. With this data, the committee was able to build on experience of previous research from their studies and other studies from institutes across the World published over the last 10 years. The manufactures were also able to incorporate new technologies in purification, quality assurance and standardisation ensuring consistency in the candidate phytochemicals. All these factor combined has resulted in establish a new generation supplement with a number of novel and attractive features:
- combines six uniquely different food types, providing a wide spectrum of natural phytochemicals, avoiding over-consumption of one particular type
- combines both whole concentrates and extracts
- minimal levels of candidate phytochemicals are measured and standardised
- contains no foods with phytoestrogen properties
- ingredients have a high safety profile
- manufactured by a well-established UK manufacturer, with high quality certification
- evaluated in previous clinical trials and found to be safe and well-tolerated.
Cohort:
Men with histologically proven, early prostate cancer early not taking androgen deprivation therapy (ADT), managed with active surveillance or watchful waiting.
Method:
Following written informed consent, all participating men (220) were given the phytochemical-rich food supplement and asked to stop all other over-the-counter supplements. There was a double-blind, randomised (1:1) allocation of the probiotic supplement or placebo. The supplements were taken twice a day for 4 months.
Results:
Men who stopped all other previous supplements and took 2 capsules of YourgutPlus with 2 capsules of YourPhyto a day had:
- A 44% slower rate prostate cancer progression measured by PSA
- MRI disease correlated with PSA & stabilised or shrunk in 91%
- A 25% improved urinary symptoms
- A 11% improvement in erectile function
- Reduced blood markers of systemic inflammation
- Enhanced grip strength and other markers of longevity
Conclusion:
This trial provides essential scientific evidence for health professionals and practical guidance for people with cancer, interested in empowering themselves with the most effective strategies to improve their well-being and help alleviate the toxicities of hormonal, radiotherapy or surgical treatments.
Abstract: Pubmed
Read full paper: European Urology Oncology Thomas R, Kenfield S, Williams M, Newton RU, Mitra A, Frazili Z Oct 2025
Lay Summary: Urology Today